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Although the real causes of the high incidences of C677T polymorphism in some areas of the world are still under study, being aware of the prevalence of these polymorphisms in different geographical areas could be helpful for clinical practice

10.1016/j.phrs.2018.06.013 60 SimoesS.LopesR.CamposM

During the development of osteoarthritis, the synovium undergoes interstitial vascularization, fibrosis and hyperplasia (167), and macrophages and fibroblasts in the synovium can release proinflammatory cytokines, etc., which cause synovitis and cartilage degeneration

One may think that it is the removal of Cu from the organism
Catal Today 225:111135
Evaluation of diet pattern and weight gain in postmenopausal women enrolled in the Womens Health Initiative Observational Study
