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Major modifications for 2025 As outlined in the 2025 Summary of Major Modifications and Explanatory Notes, the major modifications for 2025 include the following: Further examples were added to the following substance classes to help athletes and their entourage better identify prohibited substances: S0

Routine follow-ups should focus on cardiovascular vitals and assessing any changes in mood or sleep architecture

Dosage and administration: Orally via the drinking water

Central Sleep Apnoea where before being diagnosed I'd stop breathing in my sleep around 80 times per hour, which again, I now know opiates restrict breathing, has virtually now gone

The dose is often very high, as most of it will pass through your digestive system and be excreted by your body

A peptide is a short chain of amino acids joined by peptide bonds, which is the entire definition of what a peptide is