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Pre-existing mitochondrial dysfunction due to aging, diabetes, or ischemia creates a permissive environment for cuproptosis by depleting GSH and reducing SOD2 activity, thereby compromising the organelle's ability to chelate copper and neutralize mtROS [145, 146]

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Furthermore, ROCK was also able to reverse LPS-induced TER decrease and attenuate the paracellular permeability of 4-kDa FITC-dextran in Caco-2 cell monolayers

A vitamin B12 deficiency can often lead to a feeling of extreme tiredness, lack of energy and muscle weakness alongside many other symptoms