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When AR with HSP90 forms a complex state in the cytoplasm, Nano-PROTAC not only precisely degrades the AR receptor but also cleverly degrades the HSP90 that is closely bound to the AR receptor, utilizing the spatial distance self-adaptive characteristics of its nanostructure

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Mice were placed on a rod, 30 mm in diameter, rotating at 4 rpm

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As expected, no spectral responses were observed in fractions F4F6, confirming the absence of HSA in these fractions (Fig