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In one study [56] investigating the impact of NAC on noise-induced hearing loss in men ( n = 53) taking 1200 mg per day for 14 days led to a significant reduction of noise-induced temporary threshold shift, or the amount of hearing loss after a period of heightened noise exposure in a work setting relative to baseline, or pre-shift levels

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Upon chronic exposure, most of these metals accumulate in the body throughout human life and their biological effect contributes to shorten the natural lifespan of organs such as the kidney and ultimately determine their early failure [1]

The human evidence is more limited and more mixed