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Vizoviek, M., et al

Journal of biochemistry , 85 (4), 10911098

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205 A recent study showed that metformin can also regulate TJ-related protein expression by reducing the effects of TNF- on Caco-2 cell permeability, which results in inhibiting the MLCKMLC signaling pathway

Subsequent studies explained that 1-methyl-4-phenylpyridinium (MPP+), the toxic bioactive form of MPTP, undergoes oxidation by monoamine oxidase B (MAO-B) and enters the DA-producing neurons in the SN via the DA reuptake system [31]