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These characteristics make it a potential candidate for the treatment of various CNS disorders, including Alzheimers disease, multiple sclerosis, and epilepsy ( 4.4.3 Bumetanide Bumetanide is a highly effective loop diuretic that acts by inhibiting NKCC1 and NKCC2, thereby reducing intracellular Cl - concentrations and shifting the action of GABA from excitation to inhibition

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Stanton McHardy and Hua-Yu Leo Wang) at the Center for Innovative Drug Discovery, University of Texas San Antonio for the synthesis and supply of scaled batches of 5-amino-1-methylquinolinium