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Nature Neurosci ence 21(6):811-819

The most frequent symptoms include nausea (affecting approximately 18-24% of patients), diarrhoea (15-17%), vomiting (6-10%), constipation (6-13%), abdominal pain (6-10%), and dyspepsia (5-9%)

This finding highlights the importance of considering sex differences and hormonal status in preclinical evaluations to enhance clinical translation

Your dose may increase over time, but your price remains flatyou'll never pay more as your provider adjusts your dose upward

Decrease in lung inflammation is why GLP-1 meds work for asthma patients In a fun twist, that is beyond the scope of this post but worth mentioning, in the rodent models lacking GLP-1R in the brain were given tirzepatide, a GLP-1 & GIP agonist, then some of the anti-inflammatory benefits returned, suggesting GIP has an anti-inflammatory role as well

There's this extreme culture at the University of Toronto around we have to protect anyone from making too much money off this thing, so we got to be really careful and potentially even slow down its development and be really thoughtful about how we distribute it to the world so that nobody takes it and makes too much money