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doi: 10.1021/tx970136j

The PDO-based metabolic drug screening platform is becoming an essential tool for the development of personalized strategies [179]

It was observed that the upregulation of the Bcl-2 gene, which inhibits most types of apoptotic cells, and the downregulation of the Bax gene, which can promote apoptosis, were detected in cells treated with EGCG [88]

Genetic variations in the activity of glutathione-S-transferase-4, a GSH-dependent enzyme that reduces 4hydroxynonenal, is a determining factor in the extent of neurodegeneration after TBI (Al Nimer et al., 2013)

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The resulting damage intensifies cellular dysfunction and suppresses mitochondrial respiration, thereby aggravating the bioenergetic failure that underlies severe sepsis (Vctor et al., 2009