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However, current evidence is mostly from observational or single-model experiments, lacking systematic cross-tissue validation

Fluorescence/Luminescence Circadian Imaging of Complex Tissues at Single-Cell Resolution

Moreover, the gut microbiota and its metabolites have been implicated in cancer development and progression, indicating its potential as a target for therapeutic interventions in combination with cannabis-based therapies

doi: 10.1152/ajpgi.00048.2015

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In cell culture models of human macrophage foam cells, the inability to clear cholesterol from macrophages with compromised lysosome function continues even in the presence of compounds that stimulate efflux (161,163)
